Pantoprazole

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Pantoprazole

Pantoprazole drug image

Brand Protonix

     Form Oral Tablet

     Drug Type Proton-Pump Inhibitors

 

Pantoprazole treats certain stomach and esophagus problems (such as acid reflux). It works by decreasing the amount of acid your stomach makes.

 

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Drug Information

Pantoprazole treats certain stomach and esophagus problems (such as acid reflux). It works by decreasing the amount of acid your stomach makes. This medication relieves symptoms such as heartburn, difficulty swallowing, and cough. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent esophagus cancer. Pantoprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).

Read the Medication Guide provided by your pharmacist before you start taking pantoprazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily. Dosage and length of treatment are based on your medical condition and response to treatment. If you are taking the tablets, you may take them with or without food. Swallow the tablets whole. Do not split, crush, or chew the medication. Doing so may destroy the drug. If you are taking the granules, take your dose 30 minutes before a meal. To take it by mouth, open the packet and mix the granules in applesauce or apple juice. Do not mix with other foods or liquids. Do not crush or chew the granules. Sprinkle the granules on one teaspoon (5 milliliters) of applesauce and swallow the mixture immediately (within 10 minutes). Follow with sips of water. Or you can mix the granules with one teaspoon (5 milliliters) of apple juice in a small cup, stir for 5 seconds, and swallow the mixture immediately. To ensure you take the entire dose, rinse the cup once or twice with apple juice to mix any remaining granules and swallow the juice.

Do not prepare the mixture ahead of time for later use. If you are giving the granules through a tube into the stomach (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to mix and give it properly. If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed treatment length even if you feel better. Tell your doctor if your condition lasts or gets worse.

The risk of side effects goes up over time. Ask your doctor how long you should take this medication.

Headache or diarrhea may occur. Tell your doctor or pharmacist promptly if any of these effects last or get worse. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including symptoms of a low magnesium blood level (such as muscle spasms, irregular heartbeat, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain).

This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, or blood/mucus in your stool. If you have these symptoms, do not use anti-diarrhea or opioid products because they may worsen symptoms. Rarely, proton pump inhibitors (such as pantoprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, signs of kidney problems (such as a change in the amount of urine). This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

Before taking pantoprazole, tell your doctor or pharmacist if you are allergic to it, similar drugs (such as lansoprazole or omeprazole), or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease and lupus. Some symptoms may actually be signs of a more serious condition.

Get medical help right away if you have: heartburn with lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), or unexplained weight loss. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Proton pump inhibitors (such as pantoprazole) may increase your risk for bone fractures, especially with longer use, higher doses, and in older adults. Talk with your doctor or pharmacist about ways to prevent bone loss/fracture, such as by taking calcium (such as calcium citrate) and vitamin D supplements. Older adults may be more sensitive to the side effects of this drug, especially bone loss and fractures (see above) and C. difficile infection (see Side Effects section).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Consult your doctor before breastfeeding.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all your products (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is methotrexate (especially high-dose treatment). Some products need stomach acid so that the body can absorb them properly. Pantoprazole decreases stomach acid, which may change how well these products work. Some affected products include ampicillin, atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others. This medication may interfere with certain laboratory tests (including urine tests for tetrahydrocannabinol-THC and blood tests to find certain tumors), possibly causing false test results. Make sure laboratory personnel, and all your doctors know you use this drug.

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The information provided on this page is updated periodically. Please use our Drug Search Tool for the latest information and updates about this drug. The information on this site is not intended to take the place of your doctor or other healthcare professionals. It is a resource to help you make the best decisions and get the most from the medical services available to you. A licensed physician should be consulted to diagnose and treat all medical conditions.